Positivity of oligoclonal bands in the cerebrospinal fluid predisposed to metabolic changes and rearrangement of inhibitory/excitatory neurotransmitters in subcortical brain structures in multiple sclerosis

BackgroundThe latest diagnostic criteria for multiple sclerosis (MS) have revitalized the role of oligoclonal bands synthesis in cerebrospinal fluid (CSF-OCB). This study identifies predictors CSF-OCB-positivity among vivo metabolic markers subcortical gray/white matter MS patients after their first episode (CIS) and with relapsing-remitting course (RRMS).MethodsThe enrolled 13 CIS 23 RRMS patients. Metabolism was evaluated using Mescher-Garwood-edited proton-magnetic resonance spectroscopy on a 3T MR scanner. In addition to N-acetyl-aspartate (tNAA), myoinositol (mIns), choline- creatine compounds (tCho, tCr) were also γ-aminobutyric acid (GABA) glutamate-glutamine (Glx) ratios.ResultsCSF-OCB-positivity found 76.9% 78.2% GABA Glx ratios putamen corpus callosum strongly determined CSF-OCB-positive Other essential mIns putamen, tCho/tNAA callosum. RRMS, right thalamus left hippocampus predicted tNAA/tCr identified as patients.ConclusionThis is evidence GABA-Glx rearrangement since its early stages MS.